Expression quantitative trait locus analysis identifies novel genes for statin myopathy.
نویسنده
چکیده
منابع مشابه
Identification of Key Causal Regulators in Gene Networks
One primary goal of gene network analysis is to identify key regulatory components, or key drivers, of sub-networks with respect to various biological contexts. Here we developed a general algorithm to identify key drivers in gene regulatory networks. The generalized key driver analysis (KDA) uncovers not only the well-known regulators for the expression quantitative trait locus (eQTL) hotspots...
متن کاملQuantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken.
Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping. Therefore, little is known about their molecular basis. One possible way toward finding the underlying genes is to map intermediary molecular phenotypes, such as gene expression ...
متن کاملGenome-wide meta-analysis identifies new susceptibility loci for migraine
Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility ...
متن کاملGene Set Enrichment in eQTL Data Identifies Novel Annotations and Pathway Regulators
Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene expression levels across genetic mapping populations. These gene expression phenotypes have been used for genome-wide association analyses, an analysis referred to as expression QTL (eQTL) mapping. Here, ...
متن کاملIntegrating Genome-Wide Association and eQTLs Studies Identifies the Genes and Gene Sets Associated with Diabetes
AIM To identify novel candidate genes and gene sets for diabetes. METHODS We performed an integrative analysis of genome-wide association studies (GWAS) and expression quantitative trait loci (eQTLs) data for diabetes. Summary data was driven from a large-scale GWAS of diabetes, totally involving 58,070 individuals. eQTLs dataset included 923,021 cis-eQTL for 14,329 genes and 4,732 trans-eQTL...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Circulation. Cardiovascular genetics
دوره 7 2 شماره
صفحات -
تاریخ انتشار 2014